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Last seen wowing his son by handling the late night shenanigans at the Museum of Natural History, one-time night guard Larry Daley (Stiller) is now a CEO.
On one of his visits back to the museum, he learns that most of his moonlight pals - Dexter the capuchin and belligerent tiny cowboy Jedediah (Owen Wilson) among them - are being shipped away.
Stiller underplays a little too much.
It's not nearly as much fun to watch him coolly face down a dozen spear-toting warriors as it was to watch him screaming and running from a tyrannosaurus rex.
Coming off much better is Amy Adams, who plays irrepressible Amelia Earhart.
If the producers are smart, they'll sign Adams up for a spin-off post haste.
Contains mild action and brief bad language.