The complex surgery involved transplanting composite tissue from the central part of the face and required the participation of around 100 professionals, including psychiatrists and immunologists, the prestigious Vall d'Hebron hospital said in a statement on Monday.
The hospital's transplant coordinator, Elisabeth Navas, said the donor had showed "a level of maturity that leaves one speechless".
"Someone who has decided to end their life dedicates one of their last wishes to a stranger and gives them a second chance of this magnitude."
The recipient - identified only by her first name Carme - had suffered facial tissue necrosis from a bacterial infection caused by an insect bite, affecting her ability to speak, eat and see.
"When I'm looking in the mirror at home, I'm thinking that I'm starting to look more like myself," Carme told a news conference on Monday, adding her that recovery was going very well.
For such cases requiring facial transplants, donor and recipient must share the same sex, blood group and have a similar head size.
With a population of 49.4 million, Spain has been a global leader in organ transplants for more than three decades. In 2021, it became the fourth European Union country to legalise euthanasia.
Half of the six facial transplants ever done in Spain have been performed by Vall d'Hebron staff. The Catalan hospital also carried out the world's first full face transplant in 2010.
A spokesperson for the hospital declined to say the exact date of the procedure for privacy reasons, but told Reuters it took place during the autumn of 2025.
Some 6300 organ transplants were performed last year in Spain, according to Health Ministry data, with kidney transplants being the most common.
In 2024, some 426 people received assistance in dying, government data shows.
