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On Friday, Trump announced a new US attorney general and a new US ambassador to the United Nations, and on Saturday he nominated Army General Mark Milley to replace Marine General Joseph Dunford as the chairman of the Joint Chiefs of Staff.
Trump's White House has had the highest turnover of senior-level staff of the past five presidents, according to figures compiled by the Brookings Institution think tank.
Here are some senior figures who have been fired or quit the administration since Trump took office on January 20, 2017.
John Kelly - A White House official said Trump has been in discussions for months with Nick Ayers, a top aide to Vice President Mike Pence, about replacing Kelly, a retired Marine Corps general who was hired to bring order to the chaotic Trump White House but ultimately fell out with his boss.
Matthew Whitaker - Named acting attorney general on November 7, the Trump loyalist and former US attorney in Iowa, replaced Jeff Sessions.
Whitaker immediately came under scrutiny over past remarks critical of a probe into Russian meddling in the 2016 US presidential election and any collusion between Moscow and the Trump campaign.
As acting attorney general, Whitaker took over supervision of the probe led by Special Counsel Robert Mueller. Some lawmakers feared Trump might order Whitaker to undermine the inquiry, fears Trump allies called unwarranted.
Jeff Sessions - After months of being attacked and ridiculed by the president, the former senator was forced out on November 7 as the top US law enforcement official. Sessions earlier had been a major Trump supporter. But by recusing himself from supervising the Russia probe, he shifted that duty onto Deputy Attorney General Rod Rosenstein and incurred Trump's wrath.
Nikki Haley - She said on Oct. 9 she would step down at year-end as US ambassador to the United Nations.
Don McGahn - Trump said in August the White House counsel would leave amid strains between the two over the Mueller probe.
Scott Pruitt - The Environmental Protection Agency chief quit on July 5 under fire over a series of ethics controversies.
David Shulkin - White House officials said on March 28 the Veteran Affairs secretary would resign. Shulkin had become a distraction due to a wave of speculation about his future.
H.R. McMaster - The national security adviser was replaced on March 22 with John Bolton, according to a Trump tweet.
Andrew McCabe - The deputy FBI director was fired in mid-March by Sessions. McCabe said he was targeted for being a witness into whether Trump tried to obstruct the Mueller probe.
Rex Tillerson - The secretary of state was fired by Trump on March 13 after rifts between them over international issues.
Gary Cohn - The National Economic Council director and former Goldman Sachs president said on March 5 he would resign, having lost a fight with Trump over tariffs.
Hope Hicks - The White House communications director, a long-serving and trusted Trump aide, resigned on Feb. 28.
Rob Porter - The White House staff secretary resigned in February after accusations of domestic abuse from former wives.
Omarosa Manigault Newman - Fired as assistant to the president in December, the former reality TV star later wrote a book, "Unhinged: An Insider's Account of the Trump White House."
Richard Cordray - The US Consumer Financial Protection Bureau's first director quit in November.
Tom Price - The Health and Human Services secretary quit under pressure from Trump on Sept. 29 over travel practices.
Stephen Bannon - Trump's chief strategist was fired by Trump in mid-August after clashing with White House moderates.
Anthony Scaramucci - The White House communications director was fired by Trump in July after 10 days on the job.
Reince Priebus - Replaced as chief of staff by John Kelly, Priebus lost Trump's confidence after setbacks in Congress.
Sean Spicer - Resigned as White House press secretary in July, ending a turbulent tenure.
Walter Shaub - The head of the US Office of Government Ethics, who clashed with Trump, stepped down in July.
Michael Dubke - Resigned as White House communications director in late May.
James Comey - The FBI director, who led the Russia probe before Mueller, was fired by Trump in May.
Katie Walsh - The deputy White House chief of staff was transferred out to a Republican activist group in March.
Michael Flynn - Resigned in February as Trump's national security adviser after disclosures that he discussed US sanctions on Russia with the Russian ambassador to the United States before Trump took office. Flynn later pleaded guilty to lying to the FBI. He is set to be sentenced in December.
Sally Yates - Trump fired the acting US attorney general in January after she ordered Justice Department lawyers not to enforce Trump's immigration ban.