Police were alerted to the crash, near the intersection with Conroys Rd at Butchers Dam, about 10.50am.
Initial suggestions suggested there were serious injuries, but in an update about midday Senior Sergeant Clint Wright, of Alexandra, confirmed the single occupant of the vehicle had died.
He said police inquiries were continuing and the Serious Crash Unit was on the scene.
The road reopened at about 3pm.
Earlier, a single vehicle covered by a tarpaulin was the only visible sign of the crash.
Two appliances were dispatched from Alexandra and were assisting ambulance and police at the scene.
A Hato Hone St John spokeswoman said they were notified of an incident in Conroy’s Gully at 10.48am.
One ambulance was sent to the scene.
Motorists were advised to avoid the area if possible.
