Teviot Rd between the Roxburgh Bridge and Wright Road was closed because of the accident.
A Fire and Emergency New Zealand spokeswoman said the truck came off the road while driving along Teviot Rd near Millers Flat this afternoon.
Crews from Roxburgh and Millers Flat attended shortly before 5pm.
The person trapped in he truck was helped out of the vehicle by firefighters.
A police spokeswoman said one person received moderate to serious injuries and was transported to hospital by helicopter.
Fulton Hogan maintenance department manager Malcolm Hill said Teviot Rd between the Roxburgh Bridge and Wright Road was now open after being closed due to the accident.
