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Emergency services were called to the crash in the Twizel-Omarama Rd (State Highway 8) about 12.30pm. No other vehicles were involved.
Senior Sergeant Jason McCoy, of Oamaru, confirmed a man was killed. A St John spokesman said another person suffered moderate injuries.
Snr Sgt McCoy said inquiries were continuing and witnesses were being sought and spoken to.
A Fire and Emergency New Zealand spokesman said crews from Omarama and Twizel were called to reports of a ute towing a caravan which had rolled, and helped free people who were initially trapped.
The road was down to one lane for several hours yesterday afternoon.