Coach Ryan Martin's team scored 21 tries in the Highlanders First XV game to establish a point-scoring record for the school.
The Otago Boys' High School Rugby Football Club was formed in 1871 and this was the highest winning score, and the highest winning margin, in its 141-year history.
Otago Boys' played at pace, led 80-0 at halftime and continued the onslaught in the second spell.
First five-eighth Sean Conner and midfield back Aleki Morris both scored three tries and lock Josh Dickson added two.
Dickson dominated the lineout and was mobile around the paddock with his driving runs with the ball in hand and his tackling. Hooker Ryan Williams threw accurately to the lineout.
South Otago High School won its third game of the competition - its only loss was to Otago Boys' - when it scored nine tries to beat Kavanagh College 53-7 in Balclutha.
South Otago led 24-0 at the break and continued its onslaught in the second spell.
A feature of South Otago's play was the swift delivery of ball to its speedy outside backs by the inside pairing of Dion Shaw and Caleb Edwards.
Eathorne Edwards was able to break the line in the midfield.
Lock Shae Robertson was dominant in the lineout and hooker Josh Turnbull and openside flanker Joel van Vugt were mobile around the paddock.
Midfield back Hayden Stephen scored two of Gore High School's three tries when John McGlashan College was beaten 20-12 in Dunedin. Winger Cody Sayer scored the other try.
Key players in the Gore pack were No 8 Logan McKee and flanker Dirk Morrison. The best backs were centre Matthew Collins and wing Tyson Crown.
McGlashan kept the game tight in the forwards, with its best player being No 8 Malcolm Sutherland.
In other games, Southland Boys' High School beat St Kevin's College 38-0, and Menzies College beat Dunstan High School 3-0. Waitaki Boys' High School beat King's High School 24-19 in a midweek game.
