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A police spokeswoman said emergency services were called to reports of a vehicle colliding with a parked car at the intersection of Kaikorai Valley Rd and Mellor St about 3pm today.
A photographer at the scene said emergency services worked to free a woman trapped in a car involved in the crash.
The 4WD ended up on its side against a house.
A St John spokesman said one person was taken to Dunedin Hospital with serious injuries.