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A police spokeswoman said two people were trapped after the two-car crash shortly before 2pm.
Both, seriously injured, were extracted by emergency services, the spokeswoman said.
The vehicles involved were damaged to the extent they needed to be towed and motorists were asked to avoid the area while police cleared the scene yesterday, she said.
A St John spokesman said two ambulances were sent to the crash site.
Two patients were taken to Dunedin Hospital, he said.