While the rampant South Africans surged to the top of the standings after two rounds, the injury-plagued Blues were left licking their wounds and counting just 13 players on the field.
It was the most points they have conceded in Super rugby history and it could have been more if the Bulls hadn't eased off from their rampaging start, when they raced to a 26-0 lead in 24 minutes.
The Bulls capitalised on a glut of Blues errors and turnovers, scoring seven tries to four.
First five-eighth Morne Steyn finished with 20 points from the boot while outstanding No 8 Pierre Spies bagged two tries in their second bonus point win.
The Blues also secured a bonus point but, a week after their impressive 25-19 defeat of the Western Force in Perth, this was a major let-down from coach Pat Lam's men.
Lam had exhausted his reserve bench by midway through the second spell but late injuries left the team seriously under-manned, allowing the Bulls to bag two late tries.
Of most concern were apparent knee injuries to lock Kurtis Haiu early in the game and fullback Isaia Toeava late, adding them to the medical problems plaguing the side ahead of next week's match against the Stormers in Cape Town.
Toeava was among the Blues' best, along with winger Rene Ranger and centre Anthony Tuitavake, who all scored tries.
But they came largely through unstructured play, with their forwards unable to get a firm foothold in the game.
Bulls winger Bryan Habana raced onto a grubber kick from influential halfback Fourie Du Preez inside four minutes to open the scoring, followed by a try to Dewald Potgieter which was set up by a bust from fellow loose forward Spies.
It was apparent the Blues were in for a long afternoon when fullback Zane Kirchner crossed from a simple scrum blindside move and Spies crossed for the their bonus point fourth try when he gathered a weak chip from Blues winger Paul Williams on the halfway line and galloped away from first five-eighth Jimmy Gopperth.
The Blues finally opened their account when Ranger was given space down the right touchline, followed by a slick Tuitavake try soon before halftime -- with Toeava playing a role in both.
Du Preez put the hosts 42-14 clear with 30min remaining after a slick lineout move and the game lost structure from there.
Benefiting most were the Blues, who crossed through reserve flanker Onosa'i Auva'a and Toeava but Spies his second try via a powerful surge and second five-eighth Wynand Oliver finished off the final play of the game with a classy Bulls try.
Bulls 59 (Pierre Spies 2, Bryan Habana, Dewald Potgieter, Zane Kirchner, Fourie Du Preez, Wynand Olivier tries; Morne Steyn 3 pen, 4 con, dropped goal, Burton Francis 2 con) Blues 26 (Rene Ranger, Anthony Tuitavake, Onosa'i A uva'a, Isaia Toeava tries; Jimmy Gopperth 2 con, Michael Hobbs con). Halftime: 32-14.
