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Applegate, 41, and LeNoble, 43, exchanged vows on Sunday (local time) while the entertainment world was trained on the Academy Awards, the film industry's biggest night.
The couple was "surrounded by family in a private ceremony at their home in Los Angeles," Applegate's spokeswoman said in a statement.
The couple, who have been together since 2008, engaged in 2010 and have a 2-year-old daughter, Sadie.
It is the second marriage for both.
Applegate was most recently on the television comedy "Up All Night." She announced she was leaving the NBC series in February over the show's creative direction.
LeNoble, a bassist, was a founding member of 1990s alternative rock group Porno for Pyros.