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At least nine people were killed and more than 90 wounded were taken to Kabul hospitals after a huge car bomb exploded in the Afghan capital on Wednesday (local time), a public health official said, and the casualty total could rise.
Witnesses said they saw crowds gathered around ambulances that carried the dead and wounded to hospitals, trying to identify bodies.
Basir Mujahid, a spokesman for Kabul police, said several people were killed and wounded in the blast near the fortified entrance to the German embassy.
"It was a car bomb near the German embassy, but there are several other important compounds and offices near there too. It is hard to say what the exact target is," Mujahid said.
The explosion shattered windows and blew doors off their hinges in houses hundreds of metres away.
A public health spokesman said at least 67 wounded people had been taken to hospitals around Kabul.
There was no immediate claim of responsibility for the blast. A spokesman for Taliban insurgents said he was gathering information.
Violence around Afghanistan has been rising throughout the year, as the Taliban push to defeat the US-backed government and reimpose Islamic law after their 2001 ouster in a Washington-backed invasion.
Since most international troops withdrew at the end of 2014, the Taliban have gained ground and now control or contest about 40% of the country, according to US estimates, though President Ashraf Ghani's government holds all provincial centres.
US President Donald Trump is due to decide soon on a recommendation to send 3000 to 5000 more troops to bolster the small Nato training force and US counter-terrorism mission now totalling just over 10,000.
The commander of US forces in Afghanistan, General John Nicholson, told a congressional hearing earlier this year that he needed several thousand more troops to help Afghan forces break a "stalemate" with the Taliban.